How Macrolide Antibiotics like Erythromycin Work Against Bacterial Infections

Antibiotics are drugs that kill infectious bacteria. Antibiotics do not function against virus-induced illnesses. There are different types of antibiotics, depending on the type of bacterial infection you will get.

One of them is macrolide antibiotics that treat and prevent a wide variety of bacterial infections. It works by blocking the bacteria to produce proteins that allow them to grow and reproduce until your immune system slowly kills the bacterias that cause infection.

What and How are Macrolide Antibiotics Work?

By targeting the bacterial ribosome, macrolide antibiotics inhibit protein synthesis. They bind and partly occlude the nascent peptide exit tunnel. Thus, macrolides were regarded as ‘ tunnel plugs ‘ stopping each protein’s synthesis. However, more latest proof shows that macrolides inhibit the translation of a subset of cellular proteins selectively and that their action depends crucially on the sequence of nascent proteins and the antibiotic structure.

Macrolides, therefore, arise as translation modulators rather than as worldwide protein synthesis inhibitors. Macrolide context-specific action is the foundation for controlling resistance gene expression. The brand name of Macrolide in the market is Zithromax ( azithromycin), Klacid (clarithromycin ), Erythrocin, Erymax, Erythroped A ( erythromycin), spiramycin, and Ketek (telithromycin). Fortunately, you can get them at a lower cost by using Ery discount coupon.

Uses of Macrolide Antibiotics

In treating bacterial infections connected with the following circumstances, macrolide antibiotics are only efficient. That includes the infection to ear, nose, and throat infection (otitis), chest infections (infection of the lining of the lung), skin infections (eczema), mouth (gum infection), and dental infections as well as sexually transmitted infection such as chlamydia. Once you follow the proper way of taking the medication according to your doctor’s prescription, then it must work effectively.

For prevention purposes, Macrolide antibiotics may also be prescribed by your doctor to prevent bacterial infection. For instance, if you have sickle cell illness or your spleen (splenectomy) has been removed, you may need to use antibiotics frequently to avoid infection. You may also need to take an antibiotic course if you have undergone any dental operation and are at danger of endocarditis (infection of the cardiac lining and valves).

Side Effects Of Macrolide Antibiotics

Common side effects you may encounter while taking this medication are stomach ache, diarrhea, nausea, and vomiting. Less common side effects are dizziness, stomach irritation, indigestion, and skin rashes. Also, you may rarely experience jaundice, heart arrhythmias, allergy reaction, and tinnitus. If you feel any of these, then make sure that your doctor knows that in that way she or he can advise you what else to do that will help you manage these side effects.

Interactions With Other Medicines

When two or more medications are taken simultaneously, the other may alter the impacts of one of the medicines. This is recognized as an interaction between drugs. Talk to your GP or pharmacist if you want to verify that your medication is secure to take with a macrolide antibiotic. You should also read your medicine’s patient information leaflet.

There is a tiny chance that macrolide antibiotics may reduce the efficacy of the combined oral contraceptive pill. Women who take combined oral contraceptives should use an additional method of contraception such as condoms while taking a brief macrolide antibiotic course and seven days after completion of antibiotics.

Interactions With Food

Macrolide antibiotics and food are not known to interact. Macrolide antibiotics, however, can cause irritation of the stomach, so attempt to bring them with food or milk (or just after). This decreases this side effect’s probability. Macrolide antibiotics and alcohol are not known to interact.


If you forget taking your dose of Macrolide, take it as quickly as you remember and then proceed to take your antibiotic course as usual. However, if the next dose is almost time, skip the missed dose and continue with your periodic dosing timetable. There is an increased risk if you have to take two doses closer than usual.

It is unlikely that taking an additional dose of your antibiotic Macrolide will cause you any severe damage. It will, however, improve your likelihood of having side effects such as stomach pain, diarrhoea, nausea, and vomiting. If you take more than one additional dose of your antibiotic Macrolide inadvertently, please contact your GP.


Understanding the information of the macrolide action mechanism can inform the rational design of new drugs and highlight significant translation regulatory values. Also, if you know almost everything from its precautions, side effects, and how it works, it can help you make the whole medication easy and effective.

Remember that the antibiotic may help you treat the infection, but it depends on how you responsibly take your medicine.  So follow your doctor’s prescription.